Biochem/physiol Actions

Secondary Target5-HT_2B

Primary Target5-HT_2C

General description

A selective 5-HT_2C serotonin receptor inhibitor with lesser affinity for 5-HT_2BR. Often used in conjunction with ketanserin to distinguish 5-HT_2AR and 5-HT_2CR activity. SB206553 has highest affinity for 5-HT_2CR (K_i = 3.2nM) and less for 5-HT_2BR (K_i = 5.5 nM) and 5-HT_2AR (K_i = 2,300 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ros, R. et al. 2013. PNAS.110, 348.r>Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)